NIH Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace


“This Notice of Special Interest (NOSI) encourages the translation of the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative-supported technologies from academic and other non-small business research sectors to the marketplace. Small Business Concerns (SBCs) are encouraged to submit Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications that propose to further develop, optimize, validate and scale such technologies for commercial dissemination. Additionally, SBIR and STTR applications supporting the development and commercialization of novel technologies that fit within the mission of the BRAIN Initiative are encouraged…”


“… This NOSI is intended to alert SBCs and partnering institutions that there is a need to help move useful BRAIN Initiative-developed technologies and BRAIN Initiative-relevant technologies from non-commercial laboratories into the commercial marketplace. These translational projects can be submitted through the SBIR and STTR Programs.”

“Supported research and development will include further development, optimization, validation and scaling of technologies for commercial dissemination and will likely require close collaboration between the original developers of these technologies and SBCs. These partnerships may be accomplished in a number of ways, including the use of multiple program directors/principal investigators.”

“BRAIN Priority Areas were identified in the BRAIN 2025 Report; applications from SBCs that aim to commercialize technologies relating to these priority areas are encouraged:

  1. Cell Type: identify and provide experimental access to the different brain cell types to determine their roles in health and disease.
  2. Circuit Diagrams: generate circuit diagrams that vary in resolution from synapses to the whole brain.
  3. Monitor Neural Activity: produce a dynamic picture of the functioning brain by developing and applying improved methods for large‐scale monitoring of neural activity.
  4. Interventional Tools: link brain activity to behavior with precise interventional tools that change neural circuit dynamics.
  5. Theory & Data Analysis Tools: produce conceptual foundations for understanding the biological basis of mental processes through the development of new theoretical and data analysis tools.
  6. Human Neuroscience: develop innovative technologies to understand the human brain; create and support integrated human brain research networks.
  7. Integrated Approaches: integrate new technological and conceptual approaches produced in Goals #1-6 to discover how dynamic patterns of neural activity are transformed into cognition, emotion, perception, and action in health and disease…” Read the full report here.

Source: Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace – March 3, 2021. National Institutes of Health (NIH).



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